Melvin Cooper

Characterization and formulation into solid dosage forms of a novel bacteriophage lytic against Klebsiella oxytoca.

Characterization and formulation into solid dosage forms of a novel bacteriophage lytic against Klebsiella oxytoca.

OBJECTIVETo isolate and characterize bacteriophage lytic for the opportunistic pathogen Klebsiella oxytoca and their formulation into a vary of solid dosage forms for in-vitro testing.RESULTSWe report the isolation, genomic and practical characterization of a novel bacteriophage lytic for Klebsiella oxytoca, which doesn’t infect the intently associated Klebsiella pneumoniae. This bacteriophage was formulated into suppositories and …

Characterization and formulation into solid dosage forms of a novel bacteriophage lytic against Klebsiella oxytoca. Read More »

Cross-genus rebooting of custom-made, synthetic bacteriophage genomes in L-form bacteria.

Cross-genus rebooting of custom-made, synthetic bacteriophage genomes in L-form bacteria.

Engineered bacteriophages present highly effective instruments for biotechnology, diagnostics, pathogen management, and remedy. However, present methods for phage modifying are experimentally difficult and restricted to few phages and host organisms. Viruses that focus on Gram-positive micro organism are notably troublesome to change. Here, we current a platform know-how that permits speedy, correct, and selection-free development …

Cross-genus rebooting of custom-made, synthetic bacteriophage genomes in L-form bacteria. Read More »

Microencapsulation of Salmonella-Specific Bacteriophage Felix O1 Using Spray-Drying in a pH-Responsive Formulation and Direct Compression Tableting of Powders into a Solid Oral Dosage Form.

Microencapsulation of Salmonella-Specific Bacteriophage Felix O1 Using Spray-Drying in a pH-Responsive Formulation and Direct Compression Tableting of Powders into a Solid Oral Dosage Form.

The remedy of enteric bacterial infections utilizing oral bacteriophage remedy may be difficult for the reason that harsh acidic abdomen setting renders phages inactive throughout transit by way of the gastrointestinal tract. Solid oral dosage types permitting site-specific gastrointestinal supply of excessive doses of phages, e.g., utilizing a pH or enzymatic set off, can be …

Microencapsulation of Salmonella-Specific Bacteriophage Felix O1 Using Spray-Drying in a pH-Responsive Formulation and Direct Compression Tableting of Powders into a Solid Oral Dosage Form. Read More »

MS

3 Ms2 Bacteriophages are available from Zeptometrix and Gentaur MS2 Bacteriophage 1 x 10^9 pfu/mL Bacteriophage Lambda, genomic control DNA for LOD limit of detection determination MS2 Bacteriophage 1 x 10^9 pfu/mL